HIV Env BG505_MD39_B11 SOSIP boosting trimer in complex with B11_d77.7 mouse Fab and RM20A3 Fab
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8f92
Q-score: 0.516
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) [ DOI: doi:10.1126/science.adk0582 ]
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- B11_d77.7 fab heavy chain (14 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 env bg505_md39_b11 sosip in complex with fabs b11_d77.7 and rm20a3 (Complex)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
- B11_d77.7 fab kappa light chain (11 kDa, Protein from Mus musculus)
- Bg505_md39_b11 gp120 (54 kDa, Protein from Human immunodeficiency virus)
- Bg505_md39_b11 gp41 (18 kDa, Protein from Human immunodeficiency virus)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8f9g
Q-score: 0.446
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) [ DOI: doi:10.1126/science.adk0582 ]
- V3-glycan epitope polyclonal fab heavy chain (10 kDa, Protein from Mus musculus)
- Bg505_md64_n332-gt5 gp41 (18 kDa, Protein from synthetic construct)
- Bg505_md64_n332-gt5 gp120 (54 kDa, Protein from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv env germline targeting bg505_md64_n332-gt5 sosip in complex with v3-glycan polyclonal fab isolated from immunized bg18hcgl knock-in mice v3-glycan epitope polyclonal fab heavy chain (Complex from Mus musculus)
- V3-glycan epitope polyclonal fab light chain (8 kDa, Protein from Mus musculus)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8f9m
Q-score: 0.346
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) [ DOI: doi:10.1126/science.adk0582 ]
- Bg505_md64_n332-gt5 gp41 (18 kDa, Protein from synthetic construct)
- Bg505_md64_n332-gt5 gp120 (54 kDa, Protein from synthetic construct)
- V3-glycan epitope polyclonal fab heavy chain (9 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- V3-glycan epitope polyclonal fab light chain (9 kDa, Protein from Mus musculus)
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
- Hiv env germline targeting bg505_md64_n332-gt5 sosip in complex with v3-glycan polyclonal fab isolated from immunized wild type mice, and nhp monoclonal fab rm20a3 (Complex from Mus musculus)
HIV Env BG505_MD39_B16 SOSIP boosting trimer in complex with B16_d77.5 mouse Fab and RM20A3 Fab
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vfv
Q-score: 0.495
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) [ DOI: doi:10.1126/science.adk0582 ]
- B16_d77.5 mouse fab heavy chain fv (13 kDa, Protein from Mus musculus)
- Iv env bg505_md39_b16 sosip boosting trimer in complex with b16_d77.5 mouse fab and rm20a3 fab (Complex from Human immunodeficiency virus 1)
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- B16_d77.5 mouse fab light chain fv (12 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
CryoEM structure of A/Perth/16/2009 H3 in complex with flu HA central stem VH1-18 antibody UCA6
Ray R, Nait Mohamed FA, Maurer DP, Huang J, Alpay BA, Ronsard L, Xie Z, Han J, Fernandez-Quintero M, Phan QA, Ursin RL, Vu M, Kirsch KH, Prum T, Rosado VC, Bracamonte-Moreno T, Okonkwo V, Bals J, McCarthy C, Nair U, Kanekiyo M, Ward AB, Schmidt AG, Batista FD, Lingwood D
Immunity (2024) [ Pubmed: 38670113 DOI: doi:10.1016/j.immuni.2024.03.022 ]
- An uca6 fab complex with one protomer of a h3 trimer (Complex from Homo sapiens)
- Uca6 lc fv (11 kDa, Protein from Homo sapiens)
- Hemagglutinin (62 kDa, Protein from Influenza A virus)
- Uca6 hc fv (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Ray R, Nait Mohamed FA, Maurer DP, Huang J, Alpay BA, Ronsard L, Xie Z, Han J, Fernandez-Quintero M, Phan QA, Ursin RL, Vu M, Kirsch KH, Prum T, Rosado VC, Bracamonte-Moreno T, Okonkwo V, Bals J, McCarthy C, Nair U, Kanekiyo M, Ward AB, Schmidt AG, Batista FD, Lingwood D
Immunity (2024) [ Pubmed: 38670113 DOI: doi:10.1016/j.immuni.2024.03.022 ]
- 09-1b12 fab (Complex from Homo sapiens)
- 09-1b12 hc fv (13 kDa, Protein from Homo sapiens)
- Hemagglutinin ha2 chain (28 kDa, Protein from Influenza A virus)
- Hemagglutinin ha1 chain (36 kDa, Protein from Influenza A virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- An 09-1b12 fab complex with one protomer of a h1 trimer (Complex from Influenza A virus)
- 09-1b12 lc fv (12 kDa, Protein from Homo sapiens)
Ray R, Nait Mohamed FA, Maurer DP, Huang J, Alpay BA, Ronsard L, Xie Z, Han J, Fernandez-Quintero M, Phan QA, Ursin RL, Vu M, Kirsch KH, Prum T, Rosado VC, Bracamonte-Moreno T, Okonkwo V, Bals J, McCarthy C, Nair U, Kanekiyo M, Ward AB, Schmidt AG, Batista FD, Lingwood D
Immunity (2024) [ Pubmed: 38670113 DOI: doi:10.1016/j.immuni.2024.03.022 ]
- Uca6_n55t lc fv (11 kDa, Protein from Homo sapiens)
- An uca6 fab complex with one protomer of a h3 trimer (Complex from Homo sapiens)
- Hemagglutinin ha2 chain (28 kDa, Protein from Influenza A virus)
- Hemagglutinin ha1 chain (36 kDa, Protein from Influenza A virus)
- Uca6_n55t hc fv (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Ray R, Nait Mohamed FA, Maurer DP, Huang J, Alpay BA, Ronsard L, Xie Z, Han J, Fernandez-Quintero M, Phan QA, Ursin RL, Vu M, Kirsch KH, Prum T, Rosado VC, Bracamonte-Moreno T, Okonkwo V, Bals J, McCarthy C, Nair U, Kanekiyo M, Ward AB, Schmidt AG, Batista FD, Lingwood D
Immunity (2024) [ Pubmed: 38670113 DOI: doi:10.1016/j.immuni.2024.03.022 ]
- Polyclonal fab purified from mice sera (Complex from Mus musculus)
- H3d15 pfab hc fv_polya (10 kDa, Protein from Mus musculus)
- Mice polyclonal fab complex with one protomer of a h3 trimer (Complex from Influenza A virus)
- Hemagglutinin (62 kDa, Protein from Influenza A virus)
- H3d15 pfab lc fv_polya (9 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Ray R, Nait Mohamed FA, Maurer DP, Huang J, Alpay BA, Ronsard L, Xie Z, Han J, Fernandez-Quintero M, Phan QA, Ursin RL, Vu M, Kirsch KH, Prum T, Rosado VC, Bracamonte-Moreno T, Okonkwo V, Bals J, McCarthy C, Nair U, Kanekiyo M, Ward AB, Schmidt AG, Batista FD, Lingwood D
Immunity (2024) [ Pubmed: 38670113 DOI: doi:10.1016/j.immuni.2024.03.022 ]
- H3d28 pfab hc fv_polya (10 kDa, Protein from Mus musculus)
- Polyclonal fab purified from mice sera (Complex from Mus musculus)
- A/perth/16/2009 h3 (Complex from Influenza A virus)
- Hemagglutinin (62 kDa, Protein from Influenza A virus)
- H3d28 pfab lc fv_polya (9 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Ray R, Nait Mohamed FA, Maurer DP, Huang J, Alpay BA, Ronsard L, Xie Z, Han J, Fernandez-Quintero M, Phan QA, Ursin RL, Vu M, Kirsch KH, Prum T, Rosado VC, Bracamonte-Moreno T, Okonkwo V, Bals J, McCarthy C, Nair U, Kanekiyo M, Ward AB, Schmidt AG, Batista FD, Lingwood D
Immunity (2024) [ Pubmed: 38670113 DOI: doi:10.1016/j.immuni.2024.03.022 ]
- H7d15 pfab lc fv_polya (9 kDa, Protein from Mus musculus)
- Mice polyclonal fab complex with one protomer of a h7 trimer (Complex from Influenza A virus)
- H7d15 polyclonal fab purified from mice sera (Complex from Mus musculus)
- Hemagglutinin ha1 chain (34 kDa, Protein from Influenza A virus)
- H7d15 pfab hc fv_polya (10 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hemagglutinin ha2 chain (26 kDa, Protein from Influenza A virus)